Abstract: The Natural Protected Areas are hotspots for regional disaster risk management and have become important spatial entities for both theory research and management practice. Giant Panda National Park, the pilot of the national park system that covers most provinces in China, contains complex and diverse natural conditions. Hence, it is necessary to conduct researches on prevention and control system construction in the park which is a very typical research system for this issue. In this study, four aspects were analyzed in Giant Panda National Park including geological disasters prevention and control, forest fire-prevention, forestry pests control, and epidemic disease prevention and control. This study focused on analyzing the current situation and the practical difficulties faced by the construction of the disaster prevention system, exploring solutions and ways to break the deadlock, aiming to provide a reference for other natural protected areas to carry out related constructions.